ARCHETYPE Examination of a cleavage-stage embryo (openEHR-EHR-CLUSTER.exam_embryo.v1)

ARCHETYPE IDopenEHR-EHR-CLUSTER.exam_embryo.v1
ConceptExamination of a cleavage-stage embryo
DescriptionMorphological findings obtained by microscopy of the human cleavage-stage embryo.
UseUse to record morphological observations appropriate for the cleavage-stage of human embryo development, usually as part of assisted reproduction treatment. This archetype has been specifically designed to be used in the 'Observations detail' SLOT within the 'OBSERVATION.embryo_assessment' or 'ACTION.procedure' archetype, but can also be used within other ENTRY or CLUSTER archetypes, where clinically appropriate.
MisuseNot to be used for recording observations on oocytes, zygotes and blastocysts - use specific CLUSTER archetypes for this purpose.
PurposeTo record structured observations about a human cleavage-stage embryo.
ReferencesAlpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283.

Prados, F.J., et al., The cleavage stage embryo. Human Reproduction, 2012. 27(suppl_1): p. i50-i71.
Copyright© openEHR Foundation
AuthorsAuthor name: Peter Fedorcsak
Organisation: Oslo University Hospital
Email: peter.fedorcsak@medisin.uio.no
Date originally authored: 2021-10-26
Other Details LanguageAuthor name: Peter Fedorcsak
Organisation: Oslo University Hospital
Email: peter.fedorcsak@medisin.uio.no
Date originally authored: 2021-10-26
Other Details (Language Independent)
  • Licence: This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/.
  • Custodian Organisation: openEHR Foundation
  • References: Alpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283. Prados, F.J., et al., The cleavage stage embryo. Human Reproduction, 2012. 27(suppl_1): p. i50-i71.
  • Original Namespace: org.openehr
  • Original Publisher: openEHR Foundation
  • Custodian Namespace: org.openehr
  • MD5-CAM-1.0.1: 31EAAB7D52805EA5BA18B731984C63AB
  • Build Uid: 42626015-8de0-45cd-b228-84b1a29678dc
  • Revision: 1.0.1
Keywordsin vitro, fertilization, IVF, reproductive medicine, zygote, fertilised, fertilized, oocyte, egg, fertilisation, embryo, reproduction, ART, blastocyst
Lifecyclepublished
UID6f3d8069-611c-43c5-a30d-a583c71b5850
Language useden
Citeable Identifier1246.145.2670
Revision Number1.0.1
items
Number of cellsNumber of cells: Number of cells in a cleavage-stage embryo.
FragmentationFragmentation: Cytoplasmic fragmentation in a cleavage-stage embryo.
The proportion data type can be used to record a more precise assessment.
Choice of:
  •  Coded Text
    • None [Absence of cytoplasmic fragments.]
    • Mild fragmentation [Cytoplasmic fragments cover < 10% of the total cytoplasmic volume.]
    • Moderate fragmentation [Cytoplasmic fragments cover 10 - 25% of the total cytoplasmic volume.]
    • Severe fragmentation [Cytoplasmic fragments cover > 25% of the total cytoplasmic volume.]
  •  Text
  •  Proportion
Blastomere sizeBlastomere size: Relative blastomere size.
Choice of:
  •  Coded Text
    • Equal, stage specific [Equally sized blastomeres, stage specific cell size.]
    • Unequal, stage specific [Unequally sized blastomeres, stage specific cell size.]
    • Equal, non-stage specific [Equally sized blastomeres, non-stage specific cell size.]
    • Unequal, non-stage specific [Unequally sized blastomeres, non-stage specific cell size.]
  •  Text
NucleationNucleation: Presence or absence of nuclei in the blastomeres of the cleavage-stage embryo.
Choice of:
  •  Coded Text
    • No visible nuclei [Nuclei are not visible.]
    • Mononucleation [Only a single visible nucleus in all blastomeres.]
    • Binucleation [Two visible nuclei in one blastomere.]
    • Multinucleation [Multiple visible nuclei in one blastomere.]
    • Broad multinucleation [Two or more visible nuclei in two or more blastomeres.]
  •  Text
Cytoplasmic morphologyCytoplasmic morphology: Morphology of the cytoplasm of cells in cleavage-stage embryo.
May contain description of anomalies, such as granularity, pitting, and presence of vacuoles.
Spatial distribution of cellsSpatial distribution of cells: Spatial distribution of cells in a cleavage-stage embryo.
A candidate value cannot be identified as the time of publication. If consensus can be achieved in the future, it can be added to the archetype. In the meantime, a use case-appropriate value set can be added in the template.
CompactionCompaction: Degree of compaction in a cleavage-stage embryo.
Choice of:
  •  Coded Text
    • None [Absence of compaction.]
    • Minimal [Less than 50% of the total embryonic volume is compacted.]
    • Moderate [Over 50% of the total embryonic volume is compacted.]
    • Complete [The complete volume of the embryo is compacted.]
  •  Text
Other morphological featuresOther morphological features: Additional morphological features not captured by specific parameters.
The occurrences for this data element is set to 0..* to allow for more than one morphological attribute to be added as a coded value.
Morphology gradeMorphology grade: Overall grading or score based on recorded morphological features of the cleavage-stage embryo.
Use of an established morphology assessment classification is preferred.
Other contributorsVebjørn Arntzen, Oslo University Hospital, Norway (openEHR Editor)
SB Bhattacharyya, Bhattacharyyas Clinical Records Research & Informatics LLP, India
Peter Fedorcsak, University of Oslo, Norway (openEHR Editor)
Rosane Gotardo, Systema Ltda., Brazil
Heather Grain, Llewelyn Grain Informatics, Australia
Gareth Greggains, Oslo University Hospital
Evelyn Hovenga, EJSH Consulting, Australia
Liv Laugen, ​Oslo University Hospital, Norway, Norway (openEHR Editor)
Heather Leslie, Atomica Informatics, Australia (openEHR Editor)
Manisha Mantri, C-DAC, India
Mikael Nyström, Cambio Healthcare Systems AB, Sweden
Bjørn Næss, DIPS ASA, Norway
Trine Skuland, Oslo University Hospital
Norwegian Review Summary, Nasjonal IKT HF, Norway
John Tore Valand, Haukeland Universitetssjukehus, Norway
Julius Hreinsson, Laboratory Director at Reproductive Medicine, Sahlgrenska University Hospital, Sweden
Translators
  • Norwegian Bokmål: Peter Fedorcsak, Vebjørn Arntzen, University of Oslo, Oslo University Hospital, peterfe@uio.no, varntzen@ous-hf.no