ARCHETYPE Oocyte and embryo assessment (openEHR-EHR-OBSERVATION.embryo_assessment.v1)

Name: Oocyte and embryo assessment
License: http://creativecommons.org/licenses/by-sa/4.0/

ARCHETYPE ID	openEHR-EHR-OBSERVATION.embryo_assessment.v1
Concept	Oocyte and embryo assessment
Description	Assessment of morphological features and development of a single oocyte or embryo.
Use	Use to record details about assessment of morphology and development of a single oocyte, zygote, cleavage-stage embryo or blastocyst, usually as part of assisted reproduction treatment. This OBSERVATION archetype also supports recording morphokinetic data and timed annotations obtained during time-lapse microscopy of embryo development.
Misuse	Not to be used for recording details of procedures involving oocytes and embryos, like insemination, microinjection or biopsy - use specific ACTION archetype for this purpose. Not to be used for recording non-morphological assessment of single oocyte or embryo, like genetic or metabolic tests - use relevant OBSERVATION archetype for this purpose.
Purpose	To record details about the assessment of morphology and development of a single oocyte or embryo.
References	Alpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283. Eshre Working Group on Time-lapse technology, et al., Good practice recommendations for the use of time-lapse technology. Hum Reprod Open, 2020. 2020(2): p. hoaa008. Hardarson, T., L. Van Landuyt, and G. Jones, The blastocyst. Human Reproduction, 2012. 27(suppl_1): p. i72-i91. Papale, L., et al., The zygote. Human Reproduction, 2012. 27(suppl_1): p. i22-i49. Prados, F.J., et al., The cleavage stage embryo. Human Reproduction, 2012. 27(suppl_1): p. i50-i71. Rienzi, L., et al., The oocyte. Human Reproduction, 2012. 27(suppl_1): p. i2-i21.
Copyright	© openEHR Foundation
Authors	Author name: Heather Leslie Organisation: Atomica Informatics Email: heather.leslie@atomicainformatics.com Date originally authored: 2021-10-28
Other Details Language	Author name: Heather Leslie Organisation: Atomica Informatics Email: heather.leslie@atomicainformatics.com Date originally authored: 2021-10-28
Other Details (Language Independent)	Licence: This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/. Custodian Organisation: openEHR Foundation References: Alpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283. Eshre Working Group on Time-lapse technology, et al., Good practice recommendations for the use of time-lapse technology. Hum Reprod Open, 2020. 2020(2): p. hoaa008. Hardarson, T., L. Van Landuyt, and G. Jones, The blastocyst. Human Reproduction, 2012. 27(suppl_1): p. i72-i91. Papale, L., et al., The zygote. Human Reproduction, 2012. 27(suppl_1): p. i22-i49. Prados, F.J., et al., The cleavage stage embryo. Human Reproduction, 2012. 27(suppl_1): p. i50-i71. Rienzi, L., et al., The oocyte. Human Reproduction, 2012. 27(suppl_1): p. i2-i21. Original Namespace: org.openehr Original Publisher: openEHR Foundation Custodian Namespace: org.openehr MD5-CAM-1.0.1: 582BC252D2D0A957071DDD2E092DAEEE Build Uid: 499194be-296c-4b50-8452-51ca8b9ff491 Revision: 1.0.0
Keywords	in vitro, fertilization, IVF, reproductive medicine, zygote, fertilised, fertilized, oocyte, egg, fertilisation, embryo, reproduction, ART, blastocyst, morphology, time-lapse
Lifecycle	published
UID	6bce9f1a-8cee-4dfc-89ad-c4c50a526906
Language used	en
Citeable Identifier	1246.145.2733
Revision Number	1.0.0
protocol
Extension	Extension: Additional information required to extend the model with local content or to align with other reference models or formalisms. For example: local information requirements; or additional metadata to align with FHIR. Include: All not explicitly excluded archetypes
Device	Device: Details of the device used to assess morphology and development of the oocyte or embryo. Include: openEHR-EHR-CLUSTER.device.v1 and specialisations
Culture dish ID	Culture dish ID: The unique identifier for the culture dish containing the oocyte or embryo.
Method	Method: Method for assessment of morphology and development of the oocyte or embryo. Choice of: Coded Text at0008::Manual [Morphology and development were assessed by manual microscopy.] at0009::Time-lapse [Morphology and development were assessed by automated device.] Text
data
Label	Label: Label or name identifying an oocyte or embryo.
ID	ID: The unique identifier for the oocyte or embryo. For example: the entire or applicable part of the "Single European Code” or “SEC” identifier. Choice of: Identifier Text
Description	Description: General description of the oocyte or embryo.
Developmental stage	Developmental stage: Developmental stage of the oocyte or embryo. Choice of: Coded Text at0043::Oocyte [Oocyte stage.] at0037::Pronuclear stage [Pronuclear zygote stage.] at0038::2-cell stage [2-cell stage.] at0039::4-cell stage [4-cell stage.] at0040::8-cell stage [8-cell stage.] at0041::Morula [Morula stage.] at0042::Blastocyst [Blastocyst stage.] Text
Developmental event	Developmental event: Recording of a developmental event observed during time-lapse microscopy. Value set drawn from the Eshre Working Group's 'Nomenclature of morphokinetic parameters'. For example: extrusion of second polar body, appearance and fading of pronuclei, cell divisions, or compaction. Choice of: Text Coded Text at0045::tPB2 extrusion [The second polar body is completely detached from the oolemma.] at0046::tPNa [Appearance of individual pronuclei.] at0047::tPNf [Fading of pronuclei.] at0048::t2 [The embryo reaches 2 blastomeres.] at0049::t3 [The embryo reaches 3 blastomeres.] at0050::t4 [The embryo reaches 4 blastomeres.] at0051::t5 [The embryo reaches 5 blastomeres.] at0052::t6 [The embryo reaches 6 blastomeres.] at0053::t7 [The embryo reaches 7 blastomeres.] at0054::t8 [The embryo reaches 8 blastomeres.] at0055::tSC [Evidence of compaction.] at0056::tM [Completion of compaction process.] at0057::tSB [Initiation of blastulation.] at0058::tB [Full blastocyst.] at0059::tE [Initiation of expansion.] at0060::tHN [Herniation.] at0061::tHB [Fully hatched blastocyst.]
Morphological findings	Morphological findings: Structured morphological findings appropriate for the developmental stage of the oocyte or embryo. Include: openEHR-EHR-CLUSTER.exam_embryo.v1 or openEHR-EHR-CLUSTER.exam_blastocyst.v1 or openEHR-EHR-CLUSTER.exam_oocyte.v1 or openEHR-EHR-CLUSTER.exam_zygote.v1
Image representation	Image representation: Digital image, video or diagram representing morphology and development of the oocyte or embryo. Include: openEHR-EHR-CLUSTER.media_file.v1 and specialisations
Time post-insemination	Time post-insemination: The duration since insemination.
Interpretation	Interpretation: Clinical interpretation of the morphological and developmental assessment of the oocyte or embryo. For example: 'Suitable for clinical use'; or 'Unsuitable for clinical use'.
Comment	Comment: Additional narrative about the oocyte or embryo assessment, not captured in other fields. For example: difficulties in visualisation.
events
Any event	Any event: Default, unspecified point in time or interval event which may be explicitly defined in a template or at run-time.
Oocyte collection assessment	Oocyte collection assessment: Observation of the oocyte at oocyte collection.
Fertilisation assessment	Fertilisation assessment: Observation of the inseminated oocyte to assess fertilization.
Syngamy assessment	Syngamy assessment: Observation of the inseminated oocyte to assess syngamy.
Early cleavage assessment	Early cleavage assessment: Observation of the embryo to assess early first cell cleavage.
Day-2 embryo assessment	Day-2 embryo assessment: Embryo observation on Day 2 post insemination.
Day-3 embryo assessment	Day-3 embryo assessment: Embryo observation on Day 3 post insemination.
Day-4 embryo assessment	Day-4 embryo assessment: Embryo observation on Day 4 post insemination.
Day-5 embryo assessment	Day-5 embryo assessment: Embryo observation on Day 5 post insemination.
Day-6 embryo assessment	Day-6 embryo assessment: Embryo observation on Day 6 post insemination.
Freezing assessment	Freezing assessment: Oocyte or embryo observation at cryopreservation.
Thawing assessment	Thawing assessment: Oocyte or embryo observation at thawing.
Embryo transfer assessment	Embryo transfer assessment: Embryo observation at embryo transfer.
Other contributors	Vebjørn Arntzen, Oslo University Hospital, Norway (openEHR Editor) Silje Ljosland Bakke, Helse Vest IKT AS, Norway SB Bhattacharyya, Bhattacharyyas Clinical Records Research & Informatics LLP, India Gunn Elin Blakkisrud, DIPS ASA, Norway Peter Fedorcsak, University of Oslo, Norway (openEHR Editor) Rosane Gotardo, Systema Ltda., Brazil Heather Grain, Llewelyn Grain Informatics, Australia Liv Laugen, Oslo University Hospital, Norway, Norway (openEHR Editor) Heather Leslie, Atomica Informatics, Australia (openEHR Editor) Manisha Mantri, C-DAC, India Mikael Nyström, Cambio Healthcare Systems AB, Sweden Norwegian Review Summary, Nasjonal IKT HF, Norway John Tore Valand, Haukeland Universitetssjukehus, Norway Julius Hreinsson, Laboratory Director at Reproductive Medicine, Sahlgrenska University Hospital, Sweden
Translators	Norwegian Bokmål: Peter Fedorcsak, Vebjørn Arntzen, University of Oslo, Oslo University Hospital, peterfe@uio.no, varntzen@ous-hf.no