<?xml version="1.0" encoding="UTF-8"?>
<archetype xmlns="http://schemas.openehr.org/v1" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <original_language>
    <terminology_id>
      <value>ISO_639-1</value>
    </terminology_id>
    <code_string>de</code_string>
  </original_language>
  <is_controlled>false</is_controlled>
  <description>
    <original_author id="date">2019-04-02</original_author>
    <original_author id="name">Katrin Tröltzsch</original_author>
    <original_author id="organisation">Heidelberg University Hospital</original_author>
    <original_author id="email">katrin.troeltzsch@med.uni-heidelberg.de</original_author>
    <other_contributors>Carina Lerch Heidelberg University Hospital</other_contributors>
    <lifecycle_state>published</lifecycle_state>
    <other_details id="custodian_organisation">HiGHmed</other_details>
    <other_details id="references">Datenkatalog mit Merkmalsausprägungen nach ADT/GEKID Basisdatensatz 2.0.0 für Tumorzentren, Onkologische Schwerpunkte, Krankenhäuser und niedergelassene Ärzte&#xD;
http://www.krebsregister-bw.de/fileadmin/filemount/allgemein/download/Melder/DatenkatalogADTGEKID2.0.0_V4_Web.pdf; zuletzt aufgerufen: 24.07.2019</other_details>
    <other_details id="original_namespace">org.highmed</other_details>
    <other_details id="custodian_namespace">org.highmed</other_details>
    <other_details id="original_publisher">HiGHmed</other_details>
    <other_details id="MD5-CAM-1.0.1">411F7175E953C02AEAEB6733B35B9369</other_details>
    <other_details id="build_uid">cbb59ad1-7bb7-484a-b84c-5f70030897b3</other_details>
    <other_details id="revision">1.0.2</other_details>
    <details>
      <language>
        <terminology_id>
          <value>ISO_639-1</value>
        </terminology_id>
        <code_string>de</code_string>
      </language>
      <purpose>Zur Darstellung des histologischen Differenzierungsgrades der Tumorzellen. Das Grading beschreibt den Grad der histologischen Veränderung des Tumorgewebes.</purpose>
      <keywords>Histologie</keywords>
      <keywords>Grading</keywords>
      <keywords>Differenzierungsgrad</keywords>
      <keywords>Tumorzellen</keywords>
      <keywords>Beurteilung</keywords>
      <use>Dieser Archetyp soll verwendet werden, um den Differenzierungsgrad der Tumorzellen histologisch darzustellen. Es soll festgestellt werden, ob die Tumorzellen gut, mäßig, schlecht oder undifferenziert sind. Zudem wird bestimmt, ob niedriggradig maligne, mittelgradig maligne oder hochgradig maligne Tumorzellen vorliegen.  Dieser Archetyp kann in dem Slot "Spezifische Details" des übergeordneten Archetypen "Problem/Diagnose" (openEHR-EHR-EVALUATION.problem_diagnosis) eingebettet werden.</use>
      <misuse>Nicht geeignet zur Darstellung von histopathologischen Untersuchungsbefunden. Hier bitte den Archetyp openEHR-EHR-CLUSTER.anatomical_pathology_exam verwenden.</misuse>
      <copyright />
    </details>
    <details>
      <language>
        <terminology_id>
          <value>ISO_639-1</value>
        </terminology_id>
        <code_string>en</code_string>
      </language>
      <purpose>To record the histological degree of differentiation of the tumor cells. Grading describes the degree of histological change in the tumor tissue.</purpose>
      <keywords>Histology</keywords>
      <keywords>Grading</keywords>
      <keywords>Degree of differentiation</keywords>
      <keywords>Tumor cells</keywords>
      <keywords>Assessment</keywords>
      <use>This archetype should be used to histologically represent the degree of differentiation of the tumor cells. The aim is to determine whether the tumor cells are good, moderate, poor or undifferentiated. It is also determined whether low-grade malignant, moderately malignant or high-grade malignant tumor cells are present. This archetype can be embedded in the Specific Details slot of the parent Problem/Diagnosis archetype (openEHR-EHR-EVALUATION.problem_diagnosis).</use>
      <misuse>Not to be used to record histopathological examination findings. &#xD;
Use the openEHR-EHR-CLUSTER.anatomical_pathology_exam instead.</misuse>
      <copyright />
    </details>
  </description>
  <translations>
    <language>
      <terminology_id>
        <value>ISO_639-1</value>
      </terminology_id>
      <code_string>en</code_string>
    </language>
    <author id="name">Severin Kohler</author>
    <author id="organisation">Charite Berlin</author>
    <author id="email">severin.kohler@bih-charite.de</author>
  </translations>
  <uid>
    <value>35243628-e8c8-468b-a27d-e952e206e26f</value>
  </uid>
  <archetype_id>
    <value>openEHR-EHR-CLUSTER.histology_grading.v1</value>
  </archetype_id>
  <adl_version>1.4</adl_version>
  <concept>at0000</concept>
  <definition>
    <rm_type_name>CLUSTER</rm_type_name>
    <occurrences>
      <lower_included>true</lower_included>
      <upper_included>true</upper_included>
      <lower_unbounded>false</lower_unbounded>
      <upper_unbounded>false</upper_unbounded>
      <lower>1</lower>
      <upper>1</upper>
    </occurrences>
    <node_id>at0000</node_id>
    <attributes xsi:type="C_MULTIPLE_ATTRIBUTE">
      <rm_attribute_name>items</rm_attribute_name>
      <existence>
        <lower_included>true</lower_included>
        <upper_included>true</upper_included>
        <lower_unbounded>false</lower_unbounded>
        <upper_unbounded>false</upper_unbounded>
        <lower>1</lower>
        <upper>1</upper>
      </existence>
      <children xsi:type="C_COMPLEX_OBJECT">
        <rm_type_name>ELEMENT</rm_type_name>
        <occurrences>
          <lower_included>true</lower_included>
          <upper_included>true</upper_included>
          <lower_unbounded>false</lower_unbounded>
          <upper_unbounded>false</upper_unbounded>
          <lower>1</lower>
          <upper>1</upper>
        </occurrences>
        <node_id>at0001</node_id>
        <attributes xsi:type="C_SINGLE_ATTRIBUTE">
          <rm_attribute_name>value</rm_attribute_name>
          <existence>
            <lower_included>true</lower_included>
            <upper_included>true</upper_included>
            <lower_unbounded>false</lower_unbounded>
            <upper_unbounded>false</upper_unbounded>
            <lower>0</lower>
            <upper>1</upper>
          </existence>
          <children xsi:type="C_COMPLEX_OBJECT">
            <rm_type_name>DV_CODED_TEXT</rm_type_name>
            <occurrences>
              <lower_included>true</lower_included>
              <upper_included>true</upper_included>
              <lower_unbounded>false</lower_unbounded>
              <upper_unbounded>false</upper_unbounded>
              <lower>1</lower>
              <upper>1</upper>
            </occurrences>
            <node_id />
            <attributes xsi:type="C_SINGLE_ATTRIBUTE">
              <rm_attribute_name>defining_code</rm_attribute_name>
              <existence>
                <lower_included>true</lower_included>
                <upper_included>true</upper_included>
                <lower_unbounded>false</lower_unbounded>
                <upper_unbounded>false</upper_unbounded>
                <lower>1</lower>
                <upper>1</upper>
              </existence>
              <children xsi:type="C_CODE_PHRASE">
                <rm_type_name>CODE_PHRASE</rm_type_name>
                <occurrences>
                  <lower_included>true</lower_included>
                  <upper_included>true</upper_included>
                  <lower_unbounded>false</lower_unbounded>
                  <upper_unbounded>false</upper_unbounded>
                  <lower>1</lower>
                  <upper>1</upper>
                </occurrences>
                <node_id />
                <terminology_id>
                  <value>local</value>
                </terminology_id>
                <code_list>at0002</code_list>
                <code_list>at0003</code_list>
                <code_list>at0004</code_list>
                <code_list>at0005</code_list>
                <code_list>at0006</code_list>
                <code_list>at0007</code_list>
                <code_list>at0008</code_list>
                <code_list>at0009</code_list>
                <code_list>at0010</code_list>
                <code_list>at0011</code_list>
                <code_list>at0012</code_list>
              </children>
            </attributes>
          </children>
        </attributes>
      </children>
      <cardinality>
        <is_ordered>false</is_ordered>
        <is_unique>false</is_unique>
        <interval>
          <lower_included>true</lower_included>
          <lower_unbounded>false</lower_unbounded>
          <upper_unbounded>true</upper_unbounded>
          <lower>1</lower>
        </interval>
      </cardinality>
    </attributes>
  </definition>
  <ontology>
    <term_definitions language="de">
      <items code="at0000">
        <items id="text">Histologie Grading</items>
        <items id="description">Der Differenzierungsgrad der Tumorzellen wird histologisch beurteilt.</items>
      </items>
      <items code="at0001">
        <items id="text">Histologie Grading</items>
        <items id="description">Histologischer Differenzierungsgrad der Tumorzellen.</items>
      </items>
      <items code="at0002">
        <items id="text">G1 (Gut differenziert)</items>
        <items id="description">Die Tumorzellen sind histologisch gut differenziert.</items>
      </items>
      <items code="at0003">
        <items id="text">G2 (Mäßig differenziert)</items>
        <items id="description">Die Tumorzellen sind histologisch mäßig differenziert.</items>
      </items>
      <items code="at0004">
        <items id="text">G3 (Schlecht differenziert)</items>
        <items id="description">Die Tumorzellen sind histologisch schlecht differenziert.</items>
      </items>
      <items code="at0005">
        <items id="text">G4 (Undifferenziert)</items>
        <items id="description">Die Tumorzellen sind histologisch undifferenziert.</items>
      </items>
      <items code="at0006">
        <items id="text">Nicht bestimmbar</items>
        <items id="description">Der Differenzierungsgrad der Tumorzellen ist histologisch nicht bestimmbar.</items>
      </items>
      <items code="at0007">
        <items id="text">Niedriggradig maligne (G1-G2)</items>
        <items id="description">Die Tumorzellen sind histologisch niedriggradig bösartig differenziert.</items>
      </items>
      <items code="at0008">
        <items id="text">Mittelgradig maligne (G2-G3)</items>
        <items id="description">Die Tumorzellen sind histologisch mittelgradig bösartig differenziert.</items>
      </items>
      <items code="at0009">
        <items id="text">Hochgradig maligne (G3-G4)</items>
        <items id="description">Die Tumorzellen sind histologisch hochgradig bösartig differenziert.</items>
      </items>
      <items code="at0010">
        <items id="text">Unbekannt</items>
        <items id="description">Der histologische Differenzierungsgrad der Tumorzellen ist nicht bekannt.</items>
      </items>
      <items code="at0011">
        <items id="text">Trifft nicht zu</items>
        <items id="description">Der histologische Differenzierungsgrad der Tumorzellen trifft nicht zu, z.B. bei Gehirngewebe.</items>
      </items>
      <items code="at0012">
        <items id="text">Borderline</items>
        <items id="description">Grenzfall / Borderline (bei Ovarialtumoren).</items>
      </items>
    </term_definitions>
    <term_definitions language="en">
      <items code="at0000">
        <items id="text">Histology grading</items>
        <items id="description">The degree of differentiation of the tumor cells is assessed histologically.</items>
      </items>
      <items code="at0001">
        <items id="text">Histology grading</items>
        <items id="description">Histological degree of differentiation of the tumor cells.</items>
      </items>
      <items code="at0002">
        <items id="text">G1 (Well differentiated)</items>
        <items id="description">The tumor cells are histologically well differentiated.</items>
      </items>
      <items code="at0003">
        <items id="text">G2 (Moderately differentiated)</items>
        <items id="description">Histologically, the tumor cells are moderately differentiated.</items>
      </items>
      <items code="at0004">
        <items id="text">G3 (poorly differentiated)</items>
        <items id="description">The tumor cells are histologically poorly differentiated.</items>
      </items>
      <items code="at0005">
        <items id="text">G4 (Undifferentiated)</items>
        <items id="description">The tumor cells are histologically undifferentiated.</items>
      </items>
      <items code="at0006">
        <items id="text">Not definable</items>
        <items id="description">The degree of differentiation of the tumor cells cannot be determined histologically.</items>
      </items>
      <items code="at0007">
        <items id="text">Low-grade malignancy (G1-G2)</items>
        <items id="description">Histologically, the tumor cells have a low-grade malignant differentiation.</items>
      </items>
      <items code="at0008">
        <items id="text">Moderately malignant (G2-G3)</items>
        <items id="description">Histologically, the tumor cells are differentiated to a moderate degree of malignancy.</items>
      </items>
      <items code="at0009">
        <items id="text">Highly malignant (G3-G4)</items>
        <items id="description">Histologically, the tumor cells are highly malignantly differentiated.</items>
      </items>
      <items code="at0010">
        <items id="text">Unknown</items>
        <items id="description">The histological degree of differentiation of the tumor cells is not known.</items>
      </items>
      <items code="at0011">
        <items id="text">Does not apply</items>
        <items id="description">The histological degree of differentiation of the tumor cells does not apply, e.g. in brain tissue.</items>
      </items>
      <items code="at0012">
        <items id="text">Borderline</items>
        <items id="description">Borderline case / borderline (with ovarian tumors).</items>
      </items>
    </term_definitions>
  </ontology>
</archetype>
